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one, 7.2) ]. Pitfalls of Concomitant Use or Discontinuation of Cytochrome P450 2D6 Inhibitors The concomitant usage of Promethazine with Codeine Oral Resolution with all cytochrome P450 2D6 inhibitors (eg., amiodarone, quinidine) may well cause a rise in codeine plasma concentrations in addition to a lessen in Lively metabolite morphine plasma conc